Although the importance of weak protein‐protein interactions has been understood since the 1980s, scant attention has been paid to this “quinary structure”. The transient nature of quinary structure facilitates dynamic sub‐cellular organization through loose grouping of proteins with multiple binding partners. Despite our growing appreciation of the quinary structure paradigm in cell biology, we do not yet understand how the many forces inside the cell – the excluded volume effect, the “stickiness” of the cytoplasm, and hydrodynamic interactions – perturb the (...) weakest functional protein interactions. We discuss the unresolved problem of how the forces in the cell modulate quinary structure, and to what extent the cell has evolved to exert control over the weakest biomolecular interactions. We conclude by highlighting the new experimental and computational tools coming on‐line for in vivo studies, which are a critical next step if we are to understand quinary structure in its native environment. (shrink)

This collection presents geography's most in-depth and sustained engagements with the void to date, demonstrating the extent to which related themes such as gaps, cracks, lacks, and emptiness perforate geography's fundamental concepts, practices, and passions.

“La Poésie Comme Exercice Spirituel” first appeared in a 1942 issue of Revue Fontaine edited by Jacques and Raissa Maritain and was subsequently republished in Wah’s 1948 text Poésie, Pensée, Perception, published by Calmann-Lévy. The following is a translation of the Fontaine version. I have noted all of the variations from the latter version in the notes. As I emphasize in my commentary, the piece is a notable display of Wahl’s eclectic range of influences. Most importantly, it shows the extent (...) to which his interest in radical empiricism and process metaphysics informs his creative approach to the intersection of poetics and metaphysics. These interests are not explicitly named in the essay, and yet their influence is pervasive. The essay also includes several moments of substantial resonance with the work of Gilles Deleuze, as noted in the commentary. (shrink)

La Kantkrise (« crise kantienne ») est un des aspects les plus étudiés de la pensée de Heinrich von Kleist, aussi bien par les historiens de la philosophie que par les germanistes. Au cours de presque un siècle de recherches sur ce thème 2, les interprètes ont identifié différemment l’œuvre de Kant – ou l’auteur, autre que Kant 3 – qui aurait déclenché cette crise 4. Pour la première fois, le présent article cherche à identifier le motif déterminant de la (...) crise dans un concept et permet de réviser l’idée même d’une « crise », entendue comme un événement ponctuel et isolé, pour lui restituer son sens d’événement intérieur, appartenant à un itinéraire intellectuel déjà engagé. Il s’agit d’un concept central pour la réflexion théologique et philosophique de la seconde moitié du XVIII e siècle, qui se trouve aussi en plusieurs textes littéraires : la « destination de l’homme » ( Bestimmung des Menschen ). (shrink)

"Ce volume propose l'analyse de la place qu'occupent les cinq sens dans cette période de transition qui conduit du Moyen Âge à la Renaissance, soit les XVe et XVIe siècles. L'approche en est résolument interdisciplinaire et confronte la théologie, la littérature, les arts figurés et les sciences. Il s'agit d'apprécier les sens dans les modes de pensée et les représentations, ainsi que leurs balances : la vue, l'ouïe et les sens réputés moins nobles, comme le goût, l'odorat et le toucher, (...) qui entretiennent des relations complexes et variables. Comment, en d'autres termes, s'opère le partage du sensible? La pensée analogique, héritée de la tradition patristique, montre à l'aube de la Renaissance des signes de faiblesse : sources du plaisir, du bonheur, voire de la béatitude, ouverture sur le monde et la beauté, les sens ne sont plus simplement des occasions de pécher, ils sont aussi l'objet d'enjeux esthétiques et jouent un rôle actif dans la création artistique grâce aux liens qui les unissent à l'imaginaire."--Page 4 of cover. (shrink)

It is a matter of fact that Europe is facing more and more crucial challenges regarding health and social care due to the demographic change and the current economic context. The recent COVID-19 pandemic has stressed this situation even further, thus highlighting the need for taking action. Active and Assisted Living technologies come as a viable approach to help facing these challenges, thanks to the high potential they have in enabling remote care and support. Broadly speaking, AAL can be referred (...) to as the use of innovative and advanced Information and Communication Technologies to create supportive, inclusive and empowering applications and environments that enable older, impaired or frail people to live independently and stay active longer in society. AAL capitalizes on the growing pervasiveness and effectiveness of sensing and computing facilities to supply the persons in need with smart assistance, by responding to their necessities of autonomy, independence, comfort, security and safety. The application scenarios addressed by AAL are complex, due to the inherent heterogeneity of the end-user population, their living arrangements, and their physical conditions or impairment. Despite aiming at diverse goals, AAL systems should share some common characteristics. They are designed to provide support in daily life in an invisible, unobtrusive and user-friendly manner. Moreover, they are conceived to be intelligent, to be able to learn and adapt to the requirements and requests of the assisted people, and to synchronise with their specific needs. Nevertheless, to ensure the uptake of AAL in society, potential users must be willing to use AAL applications and to integrate them in their daily environments and lives. In this respect, video- and audio-based AAL applications have several advantages, in terms of unobtrusiveness and information richness. Indeed, cameras and microphones are far less obtrusive with respect to the hindrance other wearable sensors may cause to one’s activities. In addition, a single camera placed in a room can record most of the activities performed in the room, thus replacing many other non-visual sensors. Currently, video-based applications are effective in recognising and monitoring the activities, the movements, and the overall conditions of the assisted individuals as well as to assess their vital parameters. Similarly, audio sensors have the potential to become one of the most important modalities for interaction with AAL systems, as they can have a large range of sensing, do not require physical presence at a particular location and are physically intangible. Moreover, relevant information about individuals’ activities and health status can derive from processing audio signals. Nevertheless, as the other side of the coin, cameras and microphones are often perceived as the most intrusive technologies from the viewpoint of the privacy of the monitored individuals. This is due to the richness of the information these technologies convey and the intimate setting where they may be deployed. Solutions able to ensure privacy preservation by context and by design, as well as to ensure high legal and ethical standards are in high demand. After the review of the current state of play and the discussion in GoodBrother, we may claim that the first solutions in this direction are starting to appear in the literature. A multidisciplinary debate among experts and stakeholders is paving the way towards AAL ensuring ergonomics, usability, acceptance and privacy preservation. The DIANA, PAAL, and VisuAAL projects are examples of this fresh approach. This report provides the reader with a review of the most recent advances in audio- and video-based monitoring technologies for AAL. It has been drafted as a collective effort of WG3 to supply an introduction to AAL, its evolution over time and its main functional and technological underpinnings. In this respect, the report contributes to the field with the outline of a new generation of ethical-aware AAL technologies and a proposal for a novel comprehensive taxonomy of AAL systems and applications. Moreover, the report allows non-technical readers to gather an overview of the main components of an AAL system and how these function and interact with the end-users. The report illustrates the state of the art of the most successful AAL applications and functions based on audio and video data, namely lifelogging and self-monitoring, remote monitoring of vital signs, emotional state recognition, food intake monitoring, activity and behaviour recognition, activity and personal assistance, gesture recognition, fall detection and prevention, mobility assessment and frailty recognition, and cognitive and motor rehabilitation. For these application scenarios, the report illustrates the state of play in terms of scientific advances, available products and research project. The open challenges are also highlighted. The report ends with an overview of the challenges, the hindrances and the opportunities posed by the uptake in real world settings of AAL technologies. In this respect, the report illustrates the current procedural and technological approaches to cope with acceptability, usability and trust in the AAL technology, by surveying strategies and approaches to co-design, to privacy preservation in video and audio data, to transparency and explainability in data processing, and to data transmission and communication. User acceptance and ethical considerations are also debated. Finally, the potentials coming from the silver economy are overviewed. (shrink)

ObjectivesPrevious studies found a general increase in prejudice against Chinese people during the first months of the pandemic. The present study aims to consider inter-individual heterogeneity in stability and change regarding prejudice involving Chinese people during the pandemic. The first objective is to identify and describe different trajectories of prejudice over a seven-month period during the pandemic. The second and third objectives are to test the association between trajectory group membership and antecedent variables such as: socio-demographic factors and two psychological (...) mechanisms, namely economic threat and global citizenship identification.MethodsA representative Canadian sample according to age, gender and province of residence, was recruited for a 10-wave survey starting from April 2020 to December 2020. First, a group-based modeling approach was used to identify trajectories of prejudice. Second, a multinomial logistic regression model was used to test associations between membership in trajectories and antecedents.ResultsFour trajectories were identified. The first three trajectories have a low, high or very high level of prejudice against Chinese people which is relatively stable over time. The fourth trajectory reports low levels of prejudice in favor of Chinese people which become more positive throughout 2020. Regarding socio-demographic factors: gender is not associated with trajectory group membership, younger people are more likely to follow the trajectory in favor of Chinese people and conservatives are more likely to follow the highest trajectories against Chinese people. Regarding some psychological mechanisms: personal but not collective economic threat is associated with the trajectory in favor of Chinese people. Finally, the highest levels of prejudice are found when the strategy of identification is more local rather than global.ConclusionThe present study shows that Canadians differ in terms of both their level and change in prejudice against Chinese people throughout the pandemic with some socio-demographic groups being more likely than others to be associated with prejudice. The results also suggest that a promising way to tackle the major social issue of prejudice is to highlight a vision of the world where individuals are all “global citizens” facing the same challenge. (shrink)

:This paper explores a form of corporeal copying which it terms mimetic communication, and explores the way it is not limited to human communication but can and does operates across species. Focusing on the way movement and vision can be seen to be at work in this kind of mimetic communication, the paper argues that it constitutes an important form of affective knowledge about both human and non-human others. Taking the work of early twentieth-century documentary filmmaker Jean Painlevé, who (...) worked extensively with marine creatures, as a case in point, it explores the way in which certain technologies – in this case, cinema – can make use of mimesis as a communicational strategy which comprises the key feature of an aesthetic practice. It examines the implications of this for the way we conceive of affective spectatorship in cinema and for the way we understand our relations with animals, especially as we seek to study them. (shrink)

:This paper explores a form of corporeal copying which it terms mimetic communication, and explores the way it is not limited to human communication but can and does operates across species. Focusing on the way movement and vision can be seen to be at work in this kind of mimetic communication, the paper argues that it constitutes an important form of affective knowledge about both human and non-human others. Taking the work of early twentieth-century documentary filmmaker Jean Painlevé, who (...) worked extensively with marine creatures, as a case in point, it explores the way in which certain technologies – in this case, cinema – can make use of mimesis as a communicational strategy which comprises the key feature of an aesthetic practice. It examines the implications of this for the way we conceive of affective spectatorship in cinema and for the way we understand our relations with animals, especially as we seek to study them. (shrink)

SummaryChallenging the common conception of Jean Bodin as an ‘anti-Aristotelian’ thinker, this article places Bodin's political thought in the context of oeconomics—the science, or art of the household—as it had developed in medieval and Renaissance commentaries on Aristotle's practical philosophy. The article argues that he thereby took part in a longstanding discussion in European political thought which saw the household as possessing a political dimension. Bodin's thought on the family is central to both his universal claims pertaining to his (...) notion of the political and his more particular interest in sovereignty and the origins of absolutism. The article explores Bodin's analysis of the household as the starting point of his inquiry into the nature of a commonwealth and the foundation of his conception of the state; it examines the relationship of la police and l'oeconomie in detail, and argues that the conjugal relationship is the determinant for Bodin's conception of absolute rule and of the origins of supreme power. (shrink)

Le but de ce volume, véritable prisme de questionnements et d’études de cas, est d’essayer de tracer, à travers les écritures de soi, les conditions d’émergence d’un moi, d’un ego, de la notion même d’individu. Nécessairement, ceux qui l’ont conçu ont dû ratisser large. Les différentes contributions analysent des cas dispersés sur plusieurs siècles, en tenant compte de plusieurs genres de récits de soi : livres de raison, journaux plus ou moins intimes, chroniques… Les présupposés sous-jacent...

CONTENTS: -/- SEZIONE I IL TUTTO E' UNO? IL RISVEGLIO DI UN PROBLEMA TRA SCOLASTICA E RINASCIMENTO Il principio omne causatum est compositum fra Tommaso e Cajetano Igor Agostini, p. 25 Parti e tutto in Montaigne. La natura e l'individuo tra frammentazione e integrazione Raffaele Carbone 45 Le minuzzarie e il tutto. Giordano bruno e la conoscenza universale Maurizio Cambi 75 -/- SEZIONE II A PARTIRE DA CARTESIO. COME PUO' ESSERE UN TUTTO L'UOMO? -/- Mente/Corpo in Cartesio. Spunti per un'interpretazione (...) mereologica Stefano Di Bella 93 Nos sumus ex Deo et pertinemus ad Deum. Appartenenza, dipendenza e relazione nel pensiero e nel lessico di Arnold Guelincx Cristina Santinelli 115 L'integrità di corpo e mente nell'"invenire" terapeutico di E. W. von Tschirnhaus Manuela Sanna 133 L'indivisibilità della natura umana e della società in Francesco Longano. Un episodio della ricezione di Locke in Italia Roberto Evangelista 147 -/- SEZIONE III L'IRROMPERE DELL'ORGANICO. LA BIOLOGIA FILOSOFICA TRA SEI E SETTECENTO -/- Convenienza e discrepanza. Parti e tutto nella Lettera 32 di Baruch Spinoza Francesco Toto 169 Mereologia della sostanza e mereologia del vivente in Leibniz Enrico Pasini 197 Teleologia e mereologia dell’organismo da Leibniz a Bonnet Francesco Piro 209 Il nesso delle parti: mereologia e scienza secondo Christian Wolff Matteo Favaretti Camposampiero 239 Il problema del tutto e delle parti. il caso del vitalismo di Montpellier Charles T. Wolfe 257 -/- SEZIONE 4 TOTALITA' CRITICHE: DALLA CRISI DEL NATURALISMO ILLUMINISTICO ALLA FILOSOFIA DELLE CULTURE -/- La logica del tutto (e delle parti di tutto, vale a dire niente) in Dom Deschamps Jean-Claude Bourdin 273 l’(in)afferabile forma. Totalità e contingenza nel pensiero di Kant tra Critica della ragion pura e Critica del giudizio Luigi Imperato 303 la relazione Parte-Tutto nel primo Schelling Giuseppe D’Anna 327 Hegel o della totalizzazione dello spazio di interiorità Vittorio Morfino 343 A partire da Kant: Begriffsbiìldung teleologica e relazione Parti-Tutto nelle indagini di Rickert sulla logica delle scienze storiche della cultura Edoardo Massimilla 359 . (shrink)

Moving from a phenomenological exploration of the role of the gaze in psychopathological experience, this chapter investigates the relationship between the sense of possibility (Ratcliffe, 2012), affectivity, and narrative self-understanding. After having provided an outline of the notion of the gaze through Jean-Paul Sartre’s work, I move to illustrate how mental illness may be associated with an alteration, and, in particular, an impoverishment, of one’s sense of possibility, rooted in the presence of certain background affects. I then set to (...) explore how engaging with self-narratives can engender experiences which have the potential to transform those affects and lead to an expansion of one’s sense of possibility. (shrink)

Jean-Marie Straub – Avant de laisser parler nos amis je voudrais savoir si vous avez quelques questions. Et puis après vous déciderez de ce que vous voulez faire, si vous voulez faire un entracte ou pas. Tout ça ne me regarde pas... Bon, ce que j’ai à dire moi avant que vous posiez deux ou trois questions – on ne va pas faire salon parce que vous allez en avoir marre – c’est que je m’étonne que vous soyez aussi (...) nombreux... D’un autre côté c’est un bateau, donc je ne m’étonne pas... Bon, mais... (shrink)

Realiza-se aqui uma análise da obra literária A Paixão Segundo G.H. (1964), de Clarice Lispector, a partir do viés filosófico existencialista, desenvolvido por Jean-Paul Sartre em sua obra O Ser e o Nada: Ensaio de Ontologia Fenomenológico (1943). Assim sendo, a obra que será objeto de estudo acompanha a jornada existencial da personagem G.H. em busca de sua própria identidade. Nesse sentido, utiliza-se aqui a teoria existencialista ateísta de Sartre, assim como o estudo realizado pelo filósofo paraense, Benedito Nunes, (...) que buscou averiguar toda a filosofia metafísica no conjunto da obra de Clarice Lispector, em seu livro Leitura de Clarice Lispector (1973) e o Drama da Linguagem: uma leitura de Clarice Lispector (1989). Por fim, o presente texto tem como objetivo averiguar as atitudes de má-fé executadas pela personagem, analisar a Angústia que intercala com sua Náusea existencial, expressados pela linguagem única de Lispector. (shrink)

This article explains what is meant by the creolizing of ideas and then demonstrates it through exploring a political observation about political illegitimacy made by eighteenth-century Genevan social and political thinker Jean-Jacques Rousseau and creolized when the nineteenth-century African-American educator and social critic Anna Julia Cooper argued that the ideal of independence that lay at the core of political doctrines of republican self-governance relied on forms of willful blindness that cloaked the ongoing dependence of all human beings on (...) one another. In conclusion, the article considers what Cooper's expansion of Rousseau's insight and creolized readings of political philosophy imply for our pursuit of just political institutions today. (shrink)

It is doubtless appropriate to read The Interpretation of Dreams according to the image of the journey which Sigmund Freud describes in a letter to Wilhelm Fliess:The whole thing is planned on the model of an imaginary walk. First comes the dark wood of the authorities , where there is no clear view and it is easy to go astray. Then there is a cavernous defile through which I lead my readers—my specimen dream with its peculiarities, its details, its indiscretions (...) and its bad jokes—and then, all at once, the high ground and the open prospect and the question: “Which way do you want to go?”1This walk has nothing of the nonchalant about it. Rather, it is strewn with tests and trials, as is usually the case in the “myth of the hero” or of the “conquistador,” which we know played a major role in Freud’s thought and in that of his disciples. The progress, in epic poetry, moves toward a discovery, the founding of a city, by means of difficult stages and combats. Every “discourse” capable of attaining a goal distant from its prolegomena finds its appropriate metaphor in the hero’s progress, or in the voyage of initiation. Discursivity then becomes the intellectual equivalent of the epic’s trajectory. At the time of its publication, Freud found his book insufficiently probing, and imperfect in its discursivity. He criticized himself for having failed to link properly his arguments . Doubt was momentarily cast on the achievement of the main goal…. But such severity was not to persist.But one can also read the work by discerning its framing devices. Several authors mentioned in the first chapter reappear at the work’s conclusion. Such a return is far from fortuitous; it is the result of an extremely well-calculated strategy. Another framing system which has been noticed by many readers is the one, shortly before the end of the book, which returns to a line from Virgil that Freud had placed as an epigraph on the title page: Flectere si nequeo superos, Acheronta movebo. This line, because of its repetition at two crucial points in the book, traces its message in the form of an emblem. When it breaks in, it makes explicit that the dream mechanism is the return of the repressed:In waking life the suppressed material in the mind is prevented from finding expression and is cut off from internal perception owing to the fact that the contradictions present in it are eliminated—one side being disposed of in favor of the other; but during the night, under the sway of an impetus towards the construction of compromises, this suppressed material finds methods and means of forcing its way into consciousness.Flectere si nequeo superos, Acheronta movebo.2 1. Sigmund Freud to Wilhelm Fliess, 6 Aug. 1899, Freud, The Origins of Psychoanalysis: Letters to Wilhelm Fliess, Drafts and Notes, 1887-1902, ed. Marie Bonaparte, Anna Freud, and Ernst Kris, trans. James Strachey , p. 290.2. Freud, The Interpretation of Dreams, ed. and trans. Strachey , p. 647; my emphasis. The Latin is translated in n. 1 on that page of Freud’s text: “If I cannot bend the High Powers, I will move the Infernal Regions.” All further references to this work, abbreviated I, will be included in the text. Another framing device is created by the theme of the prophetic dream, discussed at the outset of the first chapters and taken up again, with the ambivalence of denial and concession, in the final paragraph of the book. Jean Starobinski, professor emeritus at the University of Geneva, has devoted studies to Montaigne, Diderot, Rousseau, Saussure, and modern French poets. As an M.D., he is familiar with psychoanalysis and participates in the editorial board of La Nouvelle Revue de Psychanalyse . Some of his recent research deals with the history of melancholia; his most recent books are Montaigne in Motion and Rousseau . He was awarded the Balzan Prize in 1984. (shrink)

Advancing a creolizing reading of the eighteenth-century philosopher, Jean-Jacques Rousseau, this volume explores Rousseau’s strong resonances in Caribbean thought and politics.

L'esthetique philosophique et la philosophie de l'art connaissent un essor important, particulierement dans la tradition de philosophie analytique. Ce volume examine d'abord leurs evolutions et perspectives depuis une vingtaine d'annees, grace a un panorama general des questions vives qui s'y posent et a travers une reflexion approfondie sur la notion meme d' esthetique. Une deuxieme partie porte sur la question de la representation, l'un des secteurs le plus profondement renouveles, avec la querelle opposant les tenants du conventionnalisme et ceux du (...) realisme iconique, et l'importance renouvelee des notions de ressemblance et d'imitation qu'on avait pu croire perimees. Enfin, une troisieme partie est consacree aux notions qui s'entrecroisent dans le paradoxe de la fiction: comment et pourquoi pouvons-nous etre emus par ce que nous savons ne pas exister, le destin tragique d'Anna Karenine, par exemple? Ce recueil ouvre un acces a quelques-unes des textes les plus significatifs de l'esthetique analytique des vingt dernieres annees, tout en apportant une contribution a une forme argumentative, directe et claire d'esthetique et de philosophie de l'art. (shrink)

Avec les Pensées d’un Biologiste le moraliste rejoignait le savant, l’auteur du Journal d’un Caractère, digne successeur d’un La Rochefoucauld, tirait la leçon de ce que le savant généticien, homme de laboratoire, avait découvert et de ce que le génial vulgarisateur scientifique avait tout à la fois appris et enseigné. Le Droit d’être Naturaliste marque une nouvelle étape. Qu’il écrive ou qu’il parle, dans ses livres comme dans ses conférences, Jean Rostand possède ce don d’expression, cette force de communication, (...) qui éveille l’intérêt, la curiosité, la sympathie et qui, le plus souvent, emporte l’adhésion. Homme de Vérité par excellence, convaincu il sait convaincre. Il apporte à toutes ses entreprises, d’ordre scientifique ou littéraire, le même respect de l’exactitude, le même enthousiasme militant. L’ensemble que constitue Le Droit d’être Naturaliste en fait une œuvre particulièrement riche. A côté de textes qui sont des hommages vibrants et éclairants à des auteurs dont il a plus que d’autres de bonnes raisons de nous entretenir, tels Anna de Noailles et Maurice Maeterlinck, on trouvera, et c’est là l’essentiel de ce livre important, des essais qui sont de véritables professions de foi, des discours qui sont des manifestes, tel “Le droit d’être naturaliste” qui ouvre ce volume ou le Discours sur les Prix de Vertu qui le ferme, déclarations proprement révolutionnaires à bien des égards et dont les conséquences, les projections sur l’avenir, qu’il s’agisse de modifier le système d’enseignement actuel ou d’établir les bases d’une morale biologique, ne laissent pas d’être impressionnantes. En quelques années Jean Rostand, grand humaniste, est devenu l’un des hommes qui honorent le plus notre temps. Sa longue expérience de la solitude, la diversité et la profondeur de ses connaissances, sa passion pour la vie et les vivants, son inlassable générosité font de lui un “phénomène humain” dont les convictions ici exprimées concernent directement le destin de l’homme. (shrink)

This volume offers the first English language collection of academic essays on the post-Holocaust thought of Jean Améry, a Jewish-Austrian-Belgian essayist, journalist and literary author. Comprehensive in scope and multi-disciplinary in orientation, contributors explore central aspects of Améry's philosophical and ethical position, including dignity, responsibility, resentment, and forgiveness.

Conceptual primitives and semantic universals are the cornerstones of a semantic theory which Anna Wierzbicka has been developing for many years. Semantics: Primes and Universals is a major synthesis of her work, presenting a full and systematic exposition of that theory in a non-technical and readable way. It delineates a full set of universal concepts, as they have emerged from large-scale investigations across a wide range of languages undertaken by the author and her colleagues. On the basis of empirical (...) cross-linguistic studies it vindicates the old notion of the "psychic unity of mankind", while at the same time offering a framework for the rigorous description of different languages and cultures. (shrink)